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PPAR-alpha
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. Belongs to the nuclear hormone receptor family. NR1 subfamily. Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor |
| Chromosomal Location of mouse Ortholog: 15 E2|15 40.42 cM |
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Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; lipid binding; MDM2/MDM4 family protein binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; NFAT protein binding; nuclear receptor activity; nuclear steroid receptor activity; phosphatase binding; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling receptor activity; transcription coactivator binding; transcription factor binding; ubiquitin conjugating enzyme binding; zinc ion binding
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Biological Process:
behavioral response to nicotine; cell differentiation; cellular response to starvation; circadian regulation of gene expression; enamel mineralization; epidermis development; fatty acid metabolic process; gluconeogenesis; glucose metabolic process; hormone-mediated signaling pathway; lipid metabolic process; lipoprotein metabolic process; negative regulation of appetite; negative regulation of blood pressure; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of cholesterol storage; negative regulation of cytokine production involved in inflammatory response; negative regulation of glycolytic process; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of leukocyte cell-cell adhesion; negative regulation of macrophage derived foam cell differentiation; negative regulation of miRNA transcription; negative regulation of protein binding; negative regulation of protein kinase B signaling; negative regulation of reactive oxygen species biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of fatty acid metabolic process; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of lipid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transformation of host cell by virus; regulation of cellular ketone metabolic process; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of fatty acid metabolic process; regulation of gene expression; response to hypoxia; response to insulin; rhythmic process; wound healing
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Reference #:
P23204
(UniProtKB)
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Alt. Names/Synonyms: 4933429D07Rik; AW742785; Nr1; Nr1c1; Nuclear receptor subfamily 1 group C member 1; OTTMUSP00000027777; OTTMUSP00000027778; OTTMUSP00000027779; peroxisome proliferator activated receptor alpha; Peroxisome proliferator-activated receptor alpha; Ppar; PPAR-alpha; Ppara; PPARalpha
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Gene Symbols: Ppara
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Molecular weight:
52,347 Da
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Basal Isoelectric point:
5.78
Predict pI for various phosphorylation states
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