TBX21 Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs. Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation. Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells. Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program. T-cell specific. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  neuronal cell body; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; protein binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  cellular response to organic substance; lymphocyte migration; negative regulation of interleukin-2 production; negative regulation of T-helper 17 cell differentiation; negative regulation of T-helper 17 cell lineage commitment; negative regulation of T-helper 2 cell cytokine production; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of gene expression; positive regulation of isotype switching to IgG isotypes; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of immune response; regulation of T cell differentiation; regulation of transcription, DNA-templated; T cell differentiation
Reference #:  Q9JKD8 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000002150; T-bet; T-box 21; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Tbet; Tblym; TBT1; Tbx21; Transcription factor TBLYM
Gene Symbols: Tbx21
Molecular weight: 57,852 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
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TBX21

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene