NKCC2 Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Belongs to the SLC12A transporter family. Kidney specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component:  extracellular exosome; integral component of membrane; membrane; plasma membrane
Biological Process:  ion transmembrane transport; ion transport
Disease: Bartter Syndrome, Antenatal, Type 1
Reference #:  Q13621 (UniProtKB)
Alt. Names/Synonyms: BSC1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter; MGC48843; Na-K-2Cl cotransporter; NKCC2; NKCC2A variant A; S12A1; SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; Solute carrier family 12 member 1
Gene Symbols: SLC12A1
Molecular weight: 121,450 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein