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TRPV2
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 11|11 B2 |
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Cellular Component:
axon; axonal growth cone; cell body; cell surface; cytoplasm; endomembrane system; growth cone membrane; integral component of membrane; integral component of plasma membrane; lamellipodium; membrane; plasma membrane
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Molecular Function:
calcium channel activity; cation channel activity; identical protein binding; ion channel activity
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Biological Process:
calcium ion transmembrane transport; calcium ion transport; ion transport; negative regulation of cell proliferation; positive regulation of axon extension; positive regulation of calcium ion import; positive regulation of cold-induced thermogenesis; response to heat; response to temperature stimulus; transmembrane transport
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Reference #:
Q9WTR1
(UniProtKB)
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Alt. Names/Synonyms: GRC; growth factor regulated channel; Growth factor-regulated calcium channel; Osm-9-like TRP channel 2; OTR; OTRPC2; OTTMUSP00000006068; OTTMUSP00000006069; Transient receptor potential cation channel subfamily V member 2; transient receptor potential cation channel, subfamily V, member 2; TrpV2; vanilloid receptor-like protein 1; VRL-1; Vrl1
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Gene Symbols: Trpv2
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Molecular weight:
85,965 Da
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Basal Isoelectric point:
6.55
Predict pI for various phosphorylation states
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