TRPV2 Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 11|11 B2
Cellular Component:  axon; axonal growth cone; cell body; cell surface; cytoplasm; endomembrane system; growth cone membrane; integral component of membrane; integral component of plasma membrane; lamellipodium; membrane; plasma membrane
Molecular Function:  calcium channel activity; cation channel activity; identical protein binding; ion channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; ion transport; negative regulation of cell proliferation; positive regulation of axon extension; positive regulation of calcium ion import; positive regulation of cold-induced thermogenesis; response to heat; response to temperature stimulus; transmembrane transport
Reference #:  Q9WTR1 (UniProtKB)
Alt. Names/Synonyms: GRC; growth factor regulated channel; Growth factor-regulated calcium channel; Osm-9-like TRP channel 2; OTR; OTRPC2; OTTMUSP00000006068; OTTMUSP00000006069; Transient receptor potential cation channel subfamily V member 2; transient receptor potential cation channel, subfamily V, member 2; TrpV2; vanilloid receptor-like protein 1; VRL-1; Vrl1
Gene Symbols: Trpv2
Molecular weight: 85,965 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene