|
COPG2
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the COPG family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Motility/polarity/chemotaxis; Vesicle |
| Chromosomal Location of Human Ortholog: 6|6 A3.3 |
|
Cellular Component:
COPI vesicle coat; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus; Golgi membrane; membrane; membrane coat
|
|
Molecular Function:
structural molecule activity
|
|
Biological Process:
ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; organelle transport along microtubule; protein secretion; protein transport; vesicle-mediated transport
|
|
Reference #:
Q9QXK3
(UniProtKB)
|
|
Alt. Names/Synonyms: AW227625; coatomer protein complex, subunit gamma 2; Coatomer subunit gamma-2; Copg2; Gamma-2-coat protein; Gamma-2-COP
|
|
Gene Symbols: Copg2
|
|
Molecular weight:
97,680 Da
|
|
Basal Isoelectric point:
5.55
Predict pI for various phosphorylation states
|
