COPG2 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the COPG family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of mouse Ortholog: 6|6 A3.3
Cellular Component:  COPI vesicle coat; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus; Golgi membrane; membrane; membrane coat
Molecular Function:  structural molecule activity
Biological Process:  ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; organelle transport along microtubule; protein secretion; protein transport; vesicle-mediated transport
Reference #:  Q9QXK3 (UniProtKB)
Alt. Names/Synonyms: AW227625; coatomer protein complex, subunit gamma 2; Coatomer subunit gamma-2; Copg2; Gamma-2-coat protein; Gamma-2-COP
Gene Symbols: Copg2
Molecular weight: 97,680 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene