RAB13 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. Belongs to the small GTPase superfamily. Rab family. Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 3 F1|3 39.21 cM
Cellular Component:  bicellular tight junction; cell junction; cell projection; cell-cell junction; cytoplasmic vesicle; cytosol; endocytic vesicle; endosome; extrinsic component of plasma membrane; Golgi apparatus; insulin-responsive compartment; lamellipodium; lateral plasma membrane; membrane; neuron projection; plasma membrane; recycling endosome; trans-Golgi network
Molecular Function:  GTP binding; GTPase activity; nucleotide binding; protein kinase A catalytic subunit binding
Biological Process:  bicellular tight junction assembly; cellular response to insulin stimulus; cortical actin cytoskeleton organization; endocytic recycling; endosomal transport; endothelial cell chemotaxis; establishment of Sertoli cell barrier; intracellular protein transport; neuron projection development; protein kinase A signaling; protein localization to cell leading edge; protein localization to plasma membrane; protein transport; Rab protein signal transduction
Reference #:  Q9DD03 (UniProtKB)
Alt. Names/Synonyms: 0610007N03Rik; B230212B15Rik; OTTMUSP00000024637; Rab13; RAB13, member RAS oncogene family; Ras-related protein Rab-13
Gene Symbols: Rab13
Molecular weight: 22,770 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene