STC1 Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia. Belongs to the stanniocalcin family. Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component:  apical plasma membrane; cytoplasm; extracellular space; nucleus
Molecular Function:  hormone activity
Biological Process:  bone development; cellular calcium ion homeostasis; cellular response to cAMP; cellular response to glucocorticoid stimulus; cellular response to hypoxia; chondrocyte proliferation; decidualization; embryo implantation; endothelial cell morphogenesis; growth plate cartilage axis specification; negative regulation of calcium ion transport; negative regulation of cell migration; negative regulation of endothelial cell migration; negative regulation of renal phosphate excretion; ossification; positive regulation of calcium ion import; regulation of anion transport; regulation of cardiac muscle cell contraction; regulation of signaling receptor activity; response to vitamin D
Reference #:  P52823 (UniProtKB)
Alt. Names/Synonyms: stanniocalcin 1; Stanniocalcin-1; STC; STC-1; STC1
Gene Symbols: STC1
Molecular weight: 27,621 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein