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CXCL14
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes. Note: This description may include information from UniProtKB.
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| Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 13|13 B1 |
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Cellular Component:
extracellular region; extracellular space; Golgi apparatus
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Molecular Function:
chemokine activity; cytokine activity
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Biological Process:
antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; immune response; inner ear development; killing of cells of another organism; negative regulation of myoblast differentiation; positive regulation of natural killer cell chemotaxis
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Reference #:
Q9WUQ5
(UniProtKB)
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Alt. Names/Synonyms: 1110031L23Rik; 1200006I23Rik; AI414372; B-cell and monocyte-activating chemokine; Bmac; bolekine; BRAK; C-X-C motif chemokine 14; chemokine (C-X-C motif) ligand 14; Chemokine BRAK; Cxcl14; CXL14; Kec; Kidney-expressed chemokine CXC; Ks1; MGC90667; MIP-; MIP-2G; Mip2g; MIP2gamma; musculus CXC chemokine MIP-2gamma; NJAC; Scyb1; Scyb14; small inducible cytokine subfamily B (Cys-X-Cys), member 14; Small-inducible cytokine B14
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Gene Symbols: Cxcl14
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Molecular weight:
11,716 Da
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Basal Isoelectric point:
9.91
Predict pI for various phosphorylation states
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