CXCL14 Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component:  extracellular space; Golgi apparatus
Molecular Function:  chemokine activity; protein binding
Biological Process:  cell chemotaxis; cell-cell signaling; chemotaxis; immune response; inner ear development; negative regulation of myoblast differentiation; positive regulation of natural killer cell chemotaxis; regulation of signaling receptor activity; signal transduction
Reference #:  O95715 (UniProtKB)
Alt. Names/Synonyms: BMAC; bolekine; BRAK; breast and kidney; C-X-C motif chemokine 14; C-X-C motif chemokine ligand 14; chemokine (C-X-C motif) ligand 14; Chemokine BRAK; CXC chemokine in breast and kidney; CXCL14; CXL14; KEC; KS1; MGC10687; MIP-2 gamma; MIP-2G; MIP2G; NJAC; SCYB14; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK); Small-inducible cytokine B14; tumor-suppressing chemokine
Gene Symbols: CXCL14
Molecular weight: 13,078 Da
Basal Isoelectric point: 10.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein