UQCRC2 This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 1.10.2.2; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 16p12.2
Cellular Component:  mitochondrial inner membrane; mitochondrial respiratory chain complex III; mitochondrial respiratory chain complex IV; mitochondrion; nucleoplasm
Molecular Function:  metal ion binding; metalloendopeptidase activity; protein binding
Biological Process:  aerobic respiration; cellular respiration; mitochondrial electron transport, ubiquinol to cytochrome c; oxidative phosphorylation; proteolysis
Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 5
Reference #:  P22695 (UniProtKB)
Alt. Names/Synonyms: Complex III subunit 2; Core protein II; Cytochrome b-c1 complex subunit 2, mitochondrial; cytochrome bc-1 complex core protein II; MC3DN5; QCR2; ubiquinol-cytochrome c reductase core protein 2; ubiquinol-cytochrome c reductase core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2; UQCR2; UQCRC2
Gene Symbols: UQCRC2
Molecular weight: 48,443 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UQCRC2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein