PTP4A3 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 15|15 D3
Cellular Component:  cytoplasm; endosome; membrane; nucleus; plasma membrane
Molecular Function:  hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity
Biological Process:  cellular response to leukemia inhibitory factor; dephosphorylation; endothelial cell migration; Notch signaling pathway; positive regulation of establishment of protein localization; positive regulation of NIK/NF-kappaB signaling; positive regulation of vascular permeability; protein dephosphorylation; regulation of transcription, DNA-templated; regulation of vascular endothelial growth factor signaling pathway
Reference #:  Q9D658 (UniProtKB)
Alt. Names/Synonyms: AV088979; pPtp4a3; PRL-3; Prl3; protein tyrosine phosphatase 4a3; Protein tyrosine phosphatase type IVA 3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; Ptp4a3; TP4A3
Gene Symbols: Ptp4a3
Molecular weight: 19,652 Da
Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene