TRPC7 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 5q31.1
Cellular Component:  cis-Golgi network; nuclear envelope; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  protein binding
Biological Process:  calcium ion transmembrane transport; platelet activation
Reference #:  Q9HCX4 (UniProtKB)
Alt. Names/Synonyms: hTRP7; likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7; putative capacitative calcium channel; Short transient receptor potential channel 7; transient receptor potential cation channel subfamily C member 7; transient receptor potential cation channel, subfamily C, member 7; Transient receptor protein 7; TRP-7; TRP7; TRPC7
Gene Symbols: TRPC7
Molecular weight: 99,562 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene