RAB1B The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of human Ortholog: 11q13.2
Cellular Component:  cytosol; endomembrane system; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; perinuclear region of cytoplasm; phagophore assembly site membrane; transport vesicle
Molecular Function:  G protein activity; GTP binding; GTPase activity; protein binding
Biological Process:  autophagosome assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; establishment of endothelial intestinal barrier; Golgi organization; intracellular protein transport; positive regulation of glycoprotein metabolic process; regulation of autophagosome assembly; virion assembly
Reference #:  Q9H0U4 (UniProtKB)
Alt. Names/Synonyms: RAB1B; RAB1B, member RAS oncogene family; Ras-related protein Rab-1B; small GTP-binding protein
Gene Symbols: RAB1B
Molecular weight: 22,171 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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