PLCG1 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 20q12
Cellular Component:  cell projection; cell-cell junction; COP9 signalosome; cytoplasm; cytosol; glutamatergic synapse; lamellipodium; plasma membrane; ruffle; Schaffer collateral - CA1 synapse
Molecular Function:  calcium ion binding; glutamate receptor binding; neurotrophin TRKA receptor binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; protein binding; protein kinase binding; receptor tyrosine kinase binding
Biological Process:  activation of phospholipase C activity; axon guidance; calcium-mediated signaling; cell migration; cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; in utero embryonic development; inositol phosphate metabolic process; leukocyte migration; modulation of chemical synaptic transmission; phospholipid catabolic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of epithelial cell migration; positive regulation of phospholipase C activity; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of vascular endothelial cell proliferation; signal transduction; T cell receptor signaling pathway; viral process
Reference #:  P19174 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; NCKAP3; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC-148; PLC-gamma-1; PLC-II; PLC1; PLC148; PLCG1; PLCgamma1; triphosphoinositide phosphodiesterase
Gene Symbols: PLCG1
Molecular weight: 148,532 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene