ATG5 Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established. Belongs to the ATG5 family. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 10 B2|10 23.24 cM
Cellular Component:  Atg12-Atg5-Atg16 complex; autophagosome; axoneme; cytoplasm; membrane; Mitochondria-associated ER Membrane; phagophore assembly site membrane
Molecular Function:  protein binding
Biological Process:  aggrephagy; antigen processing and presentation of endogenous antigen; apoptotic process; autophagosome assembly; autophagy; autophagy of host cells involved in interaction with symbiont; autophagy of mitochondrion; blood vessel remodeling; C-terminal protein lipidation; cellular homeostasis; cellular response to nitrogen starvation; cellular response to nitrosative stress; cellular response to starvation; heart contraction; immune system process; macroautophagy; negative regulation of apoptotic process; negative regulation of cell death; negative regulation of histone H4-K16 acetylation; negative regulation of phagocytosis; negative regulation of protein ubiquitination; negative regulation of reactive oxygen species metabolic process; negative stranded viral RNA replication; negative thymic T cell selection; otolith development; positive regulation of mucus secretion; post-translational protein modification; protein lipidation involved in autophagosome assembly; regulation of cilium assembly; regulation of cytokine secretion involved in immune response; regulation of reactive oxygen species metabolic process; regulation of release of sequestered calcium ion into cytosol; response to drug; response to fungus; vasodilation; ventricular cardiac muscle cell development
Reference #:  Q99J83 (UniProtKB)
Alt. Names/Synonyms: 2010107M05Rik; 3110067M24Rik; APG5-like; Apg5l; Atg5; Atg5l; autophagy 5-like; Autophagy protein 5; autophagy related 5; autophagy-related 5 (yeast); autophagy-related 5-like; AW319544; C88337; Pad; Paddy
Gene Symbols: Atg5
Molecular weight: 32,402 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene