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CHMP1A
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. Belongs to the SNF7 family. Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Protease |
| Chromosomal Location of human Ortholog: 16q24.3 |
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Cellular Component:
amphisome membrane; autophagosome membrane; condensed nuclear chromosome; cytosol; early endosome; endomembrane system; ESCRT III complex; kinetochore; kinetochore microtubule; lysosomal membrane; microtubule organizing center; midbody; multivesicular body; multivesicular body membrane; nuclear matrix; nuclear pore; plasma membrane
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Molecular Function:
identical protein binding; metallopeptidase activity; protein binding; protein domain specific binding; protein homodimerization activity; zinc ion binding
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Biological Process:
autophagosome maturation; autophagy; cell division; endosome transport via multivesicular body sorting pathway; ESCRT III complex disassembly; late endosome to lysosome transport; late endosome to vacuole transport; membrane fission; midbody abscission; mitotic chromosome condensation; mitotic metaphase plate congression; multivesicular body assembly; multivesicular body sorting pathway; multivesicular body-lysosome fusion; negative regulation of gene expression; nuclear membrane reassembly; nucleus organization; plasma membrane repair; protein transport; regulation of centrosome duplication; regulation of mitotic spindle assembly; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; vesicle fusion with vacuole; vesicle-mediated transport; viral budding from plasma membrane; viral budding via host ESCRT complex
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Disease: Pontocerebellar Hypoplasia, Type 8
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Reference #:
Q9HD42
(UniProtKB)
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Alt. Names/Synonyms: charged multivesicular body protein 1/chromatin modifying protein 1; Charged multivesicular body protein 1a; CHM1A; CHMP1; CHMP1A; chromatin modifying protein 1A; Chromatin-modifying protein 1a; hVps46-1; KIAA0047; PCH8; PCOLN3; procollagen (type III) N-endopeptidase; protease, metallo, 1, 33kD; PRSM1; Vacuolar protein sorting-associated protein 46-1; Vps46-1; Vps46A
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Gene Symbols: CHMP1A
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Molecular weight:
21,703 Da
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Basal Isoelectric point:
7.77
Predict pI for various phosphorylation states
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