CHMP1A Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. Belongs to the SNF7 family. Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Protease
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component:  condensed nuclear chromosome; early endosome; endomembrane system; microtubule organizing center; nuclear matrix
Molecular Function:  identical protein binding; metallopeptidase activity; protein binding; protein domain specific binding; protein homodimerization activity; zinc ion binding
Biological Process:  cell division; ESCRT III complex disassembly; gene silencing; midbody abscission; mitotic chromosome condensation; mitotic metaphase plate congression; multivesicular body assembly; negative regulation of cell cycle; negative regulation of transcription, DNA-templated; nucleus organization; proteolysis; regulation of centrosome duplication; regulation of mitotic spindle assembly; vesicle-mediated transport; viral budding via host ESCRT complex
Disease: Pontocerebellar Hypoplasia, Type 8
Reference #:  Q9HD42 (UniProtKB)
Alt. Names/Synonyms: charged multivesicular body protein 1/chromatin modifying protein 1; charged multivesicular body protein 1A; CHM1A; CHMP1; CHMP1A; chromatin modifying protein 1A; Chromatin-modifying protein 1a; hVps46-1; KIAA0047; PCH8; PCOLN3; procollagen (type III) N-endopeptidase; protease, metallo, 1, 33kD; PRSM1; Vacuolar protein sorting-associated protein 46-1; Vps46-1; Vps46A
Gene Symbols: CHMP1A
Molecular weight: 21,703 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein