TDP-43 RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 4|4 E2
Cellular Component:  cytoplasm; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding; identical protein binding; mRNA 3'-UTR binding; nucleic acid binding; protein binding; RNA binding; sequence-specific double-stranded DNA binding; single-stranded RNA binding
Biological Process:  3'-UTR-mediated mRNA stabilization; mRNA processing; negative regulation by host of viral transcription; negative regulation of gene expression; negative regulation of protein phosphorylation; nuclear inner membrane organization; positive regulation of protein import into nucleus; regulation of apoptotic process; regulation of cell cycle; regulation of circadian rhythm; regulation of protein stability; RNA splicing
Reference #:  Q921F2 (UniProtKB)
Alt. Names/Synonyms: 1190002A23Rik; C85084; OTTMUSP00000011770; OTTMUSP00000011772; OTTMUSP00000011774; OTTMUSP00000011775; TADBP; TAR DNA binding protein; TAR DNA-binding protein 43; Tardbp; TDP-4; TDP-43; Tdp4; Tdp43
Gene Symbols: Tardbp
Molecular weight: 44,548 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein