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TDP-43
RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of mouse Ortholog: 4|4 E2 |
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Cellular Component:
cytoplasm; interchromatin granule; intracellular non-membrane-bounded organelle; mitochondrion; nuclear speck; nucleoplasm; nucleus; perichromatin fibrils
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Molecular Function:
DNA binding; double-stranded DNA binding; identical protein binding; lipid binding; molecular condensate scaffold activity; mRNA 3'-UTR binding; nucleic acid binding; pre-mRNA intronic binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
3'-UTR-mediated mRNA destabilization; 3'-UTR-mediated mRNA stabilization; amyloid fibril formation; gene expression; mRNA processing; negative regulation by host of viral transcription; negative regulation of gene expression; negative regulation of protein phosphorylation; nuclear inner membrane organization; positive regulation of insulin secretion; positive regulation of protein import into nucleus; regulation of apoptotic process; regulation of cell cycle; regulation of circadian rhythm; regulation of gene expression; regulation of protein stability; rhythmic process; RNA splicing
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Reference #:
Q921F2
(UniProtKB)
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Alt. Names/Synonyms: 1190002A23Rik; C85084; OTTMUSP00000011770; OTTMUSP00000011772; OTTMUSP00000011774; OTTMUSP00000011775; TADBP; TAR DNA binding protein; TAR DNA-binding protein 43; Tardbp; TDP-4; TDP-43; Tdp4; Tdp43
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Gene Symbols: Tardbp
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Molecular weight:
44,548 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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