PDGFRA Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 4q12
Cellular Component:  cell junction; cilium; cytoplasm; external side of plasma membrane; Golgi apparatus; integral component of plasma membrane; intrinsic component of plasma membrane; microvillus; nucleus; plasma membrane; protein-containing complex
Molecular Function:  ATP binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; protein kinase activity; protein-containing complex binding; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity
Biological Process:  adrenal gland development; cardiac myofibril assembly; cell activation; cell chemotaxis; cellular response to amino acid stimulus; cellular response to reactive oxygen species; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic skeletal system morphogenesis; estrogen metabolic process; extracellular matrix organization; face morphogenesis; in utero embryonic development; Leydig cell differentiation; lung development; luteinization; male genitalia development; MAPK cascade; metanephric glomerular capillary formation; negative regulation of platelet activation; odontogenesis of dentin-containing tooth; peptidyl-tyrosine phosphorylation; phosphatidylinositol-mediated signaling; platelet aggregation; platelet-derived growth factor receptor signaling pathway; platelet-derived growth factor receptor-alpha signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C activity; positive regulation of protein kinase B signaling; protein autophosphorylation; regulation of actin cytoskeleton reorganization; regulation of chemotaxis; regulation of mesenchymal stem cell differentiation; retina vasculature development in camera-type eye; roof of mouth development; signal transduction involved in regulation of gene expression; viral process; wound healing
Disease: Gist-plus Syndrome; Hypereosinophilic Syndrome, Idiopathic
Reference #:  P16234 (UniProtKB)
Alt. Names/Synonyms: Alpha-type platelet-derived growth factor receptor; CD140; CD140 antigen-like family member A; CD140A; CD140a antigen; MGC74795; PDGF-R-alpha; PDGFR alpha; PDGFR2; PDGFRA; PGFRA; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA
Gene Symbols: PDGFRA
Molecular weight: 122,670 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PDGFRA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB