SIGLEC5 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7|7 B3
Cellular Component:  integral component of membrane; lysosome; membrane
Molecular Function:  carbohydrate binding; monosaccharide binding; sialic acid binding
Biological Process:  cell adhesion; regulation of endocytosis
Reference #:  Q920G3 (UniProtKB)
Alt. Names/Synonyms: mSiglec-F; sialic acid binding Ig-like lectin 5; sialic acid binding Ig-like lectin F; Sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin F; sialic acid-binding lectin Siglec-F; SIGL5; Siglec-5; Siglec-F; Siglec5; Siglecf
Gene Symbols: Siglec5
Molecular weight: 61,476 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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SIGLEC5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene