DDX1 Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA. (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. (Microbial infection) Required for Coronavirus IBV replication. Belongs to the DEAD box helicase family. DDX1 subfamily. Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 12|12 A1.1
Cellular Component:  cleavage body; cytoplasm; cytoplasmic stress granule; cytosol; mitochondrion; nucleoplasm; nucleus; ribonucleoprotein complex; tRNA-splicing ligase complex
Molecular Function:  ATP binding; ATP-dependent helicase activity; chromatin binding; DNA binding; DNA/RNA helicase activity; double-stranded RNA binding; exonuclease activity; helicase activity; hydrolase activity; nuclease activity; nucleic acid binding; nucleotide binding; poly(A) binding; protein binding; RNA binding; transcription coregulator activity
Biological Process:  defense response to virus; DNA duplex unwinding; double-strand break repair; immune system process; innate immune response; mRNA processing; nucleic acid phosphodiester bond hydrolysis; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of myeloid dendritic cell cytokine production; protein localization to cytoplasmic stress granule; response to exogenous dsRNA; response to virus; tRNA processing; tRNA splicing, via endonucleolytic cleavage and ligation
Reference #:  Q91VR5 (UniProtKB)
Alt. Names/Synonyms: AA409185; ATP-dependent RNA helicase DDX1; DBP-RB; Ddx1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box helicase 1; DEAD box protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
Gene Symbols: Ddx1
Molecular weight: 82,500 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene