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RFC3
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Belongs to the activator 1 small subunits family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 13q13.2 |
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Cellular Component:
Ctf18 RFC-like complex; DNA replication factor C complex; nucleoplasm; nucleus
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Molecular Function:
ATP-dependent activity, acting on DNA; DNA binding; DNA clamp loader activity; protein binding; single-stranded DNA helicase activity
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Biological Process:
DNA duplex unwinding; DNA repair; DNA replication; DNA strand elongation involved in DNA replication; DNA synthesis involved in DNA repair; DNA-templated DNA replication; positive regulation of DNA-directed DNA polymerase activity; response to organophosphorus
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Reference #:
P40938
(UniProtKB)
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Alt. Names/Synonyms: A1 38 kDa subunit; Activator 1 38 kDa subunit; Activator 1 subunit 3; MGC5276; replication factor C (activator 1) 3, 38kDa; Replication factor C 38 kDa subunit; Replication factor C subunit 3; RF-C 38 kDa subunit; RFC, 38 kD subunit; RFC3; RFC38
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Gene Symbols: RFC3
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Molecular weight:
40,556 Da
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Basal Isoelectric point:
8.66
Predict pI for various phosphorylation states
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