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RFC3
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Belongs to the activator 1 small subunits family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of Human Ortholog: 13q13.2 |
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Cellular Component:
Ctf18 RFC-like complex; DNA replication factor C complex; nucleoplasm
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Molecular Function:
DNA clamp loader activity; protein binding
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Biological Process:
DNA damage response, detection of DNA damage; DNA replication; DNA strand elongation involved in DNA replication; DNA synthesis involved in DNA repair; error-free translesion synthesis; error-prone translesion synthesis; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of DNA-directed DNA polymerase activity; regulation of signal transduction by p53 class mediator; response to organophosphorus; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair; translesion synthesis
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Reference #:
P40938
(UniProtKB)
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Alt. Names/Synonyms: A1 38 kDa subunit; Activator 1 38 kDa subunit; Activator 1 subunit 3; MGC5276; replication factor C (activator 1) 3, 38kDa; Replication factor C 38 kDa subunit; Replication factor C subunit 3; RF-C 38 kDa subunit; RFC, 38 kD subunit; RFC3; RFC38
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Gene Symbols: RFC3
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Molecular weight:
40,556 Da
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Basal Isoelectric point:
8.66
Predict pI for various phosphorylation states
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