ZDHHC3 Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25. Belongs to the DHHC palmitoyltransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of human Ortholog: 3p21.31
Cellular Component:  endoplasmic reticulum; Golgi apparatus; Golgi membrane
Molecular Function:  palmitoyltransferase activity; protein homodimerization activity; protein-cysteine S-myristoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; protein-cysteine S-stearoyltransferase activity
Biological Process:  lipoprotein localization to membrane; peptidyl-L-cysteine S-palmitoylation; positive regulation of receptor localization to synapse; positive regulation of synaptic transmission, GABAergic; protein localization to photoreceptor outer segment; protein localization to plasma membrane; protein palmitoylation; protein targeting to membrane; regulation of G protein-coupled receptor signaling pathway; TRAIL-activated apoptotic signaling pathway
Reference #:  Q9NYG2 (UniProtKB)
Alt. Names/Synonyms: Acyltransferase ZDHHC3; DHHC-3; DHHC1 protein; DHHC3; DKFZp313D2314; FLJ20209; FLJ45940; GODZ; Golgi apparatus-specific protein with DHHC zinc finger domain; golgi-specific DHHC Zinc Finger Protein; Palmitoyltransferase ZDHHC3; Protein DHHC1; ZDHC3; ZDHHC3; Zinc finger DHHC domain-containing protein 3; zinc finger DHHC-type containing 3; zinc finger DHHC-type palmitoyltransferase 3; Zinc finger protein 373; zinc finger, DHHC domain containing 3; zinc finger, DHHC-type containing 3; ZNF373
Gene Symbols: ZDHHC3
Molecular weight: 34,170 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
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ZDHHC3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein