ZDHHC3 Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25. Belongs to the DHHC palmitoyltransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of Human Ortholog: 9|9 F4
Cellular Component:  endoplasmic reticulum; Golgi apparatus; integral component of membrane; membrane; photoreceptor outer segment membrane
Molecular Function:  palmitoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; transferase activity; transferase activity, transferring acyl groups
Biological Process:  localization within membrane; peptidyl-L-cysteine S-palmitoylation; protein localization to photoreceptor outer segment; protein palmitoylation; protein targeting; protein targeting to membrane
Reference #:  Q8R173 (UniProtKB)
Alt. Names/Synonyms: 1110020O22Rik; 1810006O10Rik; 2210017C02Rik; Acyltransferase ZDHHC3; DHHC-3; GABA-A receptor-associated membrane protein 1; GOD; Godz; Golgi-specific DHHC zinc finger protein; Gramp1; OTTMUSP00000028106; Palmitoyltransferase ZDHHC3; ZDHC3; Zdhhc3; Zfp37; Zfp373; Zinc finger DHHC domain-containing protein 3; zinc finger, DHHC domain containing 3
Gene Symbols: Zdhhc3
Molecular weight: 34,041 Da
Basal Isoelectric point: 8.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene