AGPAT2 Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. Expressed predominantly in adipose tissue, pancreas and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.1.51; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; plasma membrane; specific granule membrane
Molecular Function:  1-acylglycerol-3-phosphate O-acyltransferase activity
Biological Process:  CDP-diacylglycerol biosynthetic process; epidermis development; neutrophil degranulation; phosphatidic acid biosynthetic process; phospholipid metabolic process; positive regulation of cytokine production; positive regulation of cytokine-mediated signaling pathway; response to drug
Disease: Lipodystrophy, Congenital Generalized, Type 1
Reference #:  O15120 (UniProtKB)
Alt. Names/Synonyms: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta); 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase-beta); 1-AGP acyltransferase 2; 1-AGPAT 2; 1-AGPAT2; AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-beta; Lysophosphatidic acid acyltransferase beta; lysophosphatidic acid acyltransferase-beta; PLCB
Gene Symbols: AGPAT2
Molecular weight: 30,914 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AGPAT2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein