PDE5A Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of human Ortholog: 4q26

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; metal ion binding; protein binding

Biological Process: cGMP catabolic process; negative regulation of cardiac muscle contraction; negative regulation of T cell proliferation; oocyte development; positive regulation of cardiac muscle hypertrophy; positive regulation of MAP kinase activity; positive regulation of oocyte development; regulation of nitric oxide mediated signal transduction; relaxation of cardiac muscle; signal transduction; T cell proliferation

Reference #: O76074 (UniProtKB)

Alt. Names/Synonyms: CGB-PDE; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; CN5A; PDE5; PDE5A; PDE5A1; phosphodiesterase 5A; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5

Gene Symbols: PDE5A

Molecular weight: 99,985 Da

Basal Isoelectric point: 5.74 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PDE5A

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