PTPRJ Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine

Chromosomal Location of mouse Ortholog: 2 E1|2 50.19 cM

Cellular Component: anchoring junction; cell projection; cell surface; cell-cell junction; immunological synapse; membrane; plasma membrane; ruffle membrane

Molecular Function: beta-catenin binding; cadherin binding; delta-catenin binding; gamma-catenin binding; hydrolase activity; mitogen-activated protein kinase binding; phosphatase activity; phosphoprotein phosphatase activity; platelet-derived growth factor receptor binding; protein kinase binding; protein tyrosine phosphatase activity

Biological Process: B cell differentiation; blood coagulation; calcium-mediated signaling using intracellular calcium source; dephosphorylation; glucose homeostasis; heart development; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling; negative regulation of signaling receptor activity; negative regulation of T cell receptor signaling pathway; negative regulation of vascular permeability; oligodendrocyte differentiation; peptidyl-tyrosine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of cell adhesion; positive regulation of cell-matrix adhesion; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of focal adhesion assembly; positive regulation of macrophage chemotaxis; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of platelet activation; positive regulation of protein kinase B signaling; positive regulation of tumor necrosis factor production; protein dephosphorylation; regulation of cell adhesion; vasculogenesis

Reference #: Q64455 (UniProtKB)

Alt. Names/Synonyms: AI450271; BET; Byp; CD148; colon tumor susceptibility 1; DEP-; DEP-1; HPTP beta-like tyrosine phosphatase; protein tyrosine phosphatase, receptor type, J; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; Ptpb2; PTPbeta2; Ptprj; R-PTP-eta; R-PTP-J; Receptor-type tyrosine-protein phosphatase eta; RPTPJ; Scc; Scc-; Scc-1; Scc1; Susceptibility to colon cancer 1

Gene Symbols: Ptprj

Molecular weight: 136,769 Da

Basal Isoelectric point: 5.37 Predict pI for various phosphorylation states

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PTPRJ

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