LILRB4 Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component:  integral component of membrane; plasma membrane
Molecular Function:  antigen binding; protein binding; signaling receptor activity
Biological Process:  adaptive immune response; negative regulation of osteoclast differentiation; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of protein localization to nucleus; negative regulation of T cell receptor signaling pathway; positive regulation of regulatory T cell differentiation; signal transduction
Reference #:  Q8NHJ6 (UniProtKB)
Alt. Names/Synonyms: CD85 antigen-like family member K; CD85K; HM18; ILT-3; ILT3; Immunoglobulin-like transcript 3; Leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor subfamily B member 4 soluble isoform; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; LILRB4; LILRB5; LIR-5; LIR5; LIRB4; Monocyte inhibitory receptor HM18
Gene Symbols: LILRB4
Molecular weight: 49,356 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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