LILRB4 Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 10 B3|10 25.5 cM
Cellular Component: 
Reference #:  Q64281 (UniProtKB)
Alt. Names/Synonyms: CD85K; glycoprotein 49 B; gp49; Gp49b; HM18; ILT3; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4A; Lilrb4; Lilrb4a; LIR-5; LIRB4; Mast cell surface glycoprotein Gp49B
Gene Symbols: Lilrb4
Molecular weight: 37,544 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene