VAT1 Possesses ATPase activity. Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Expressed in brain. Also expressed in glioblastoma cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  cytoplasm; membrane; mitochondrial outer membrane; mitochondrion
Molecular Function:  oxidoreductase activity; zinc ion binding
Biological Process:  negative regulation of mitochondrial fusion; oxidation-reduction process
Reference #:  Q62465 (UniProtKB)
Alt. Names/Synonyms: membrane protein of cholinergic synaptic vesicles; OTTMUSP00000002784; Synaptic vesicle membrane protein VAT-1 homolog; VAT; Vat-1; Vat1; vesicle amine transport 1; vesicle amine transport protein 1 homolog (T californica)
Gene Symbols: Vat1
Molecular weight: 43,097 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene