EMR1 Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expression is restricted to eosinophils. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component:  external side of plasma membrane
Molecular Function:  calcium ion binding
Biological Process:  adaptive immune response; cell adhesion; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway
Reference #:  Q14246 (UniProtKB)
Alt. Names/Synonyms: ADGRE1; Adhesion G protein-coupled receptor E1; AGRE1; egf-like module containing, mucin-like, hormone receptor-like 1; egf-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1; EMR1 hormone receptor; TM7LN3
Gene Symbols: ADGRE1
Molecular weight: 97,683 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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