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EMR1
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expression is restricted to eosinophils. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 17 D|17 29.8 cM |
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Cellular Component:
cell periphery; external side of plasma membrane; membrane; plasma membrane
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Molecular Function:
calcium ion binding; G protein-coupled receptor activity; transmembrane signaling receptor activity
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Biological Process:
adaptive immune response; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; immune system process; signal transduction
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Reference #:
Q61549
(UniProtKB)
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Alt. Names/Synonyms: Adgre1; Adhesion G protein-coupled receptor E1; AGRE1; Cell surface glycoprotein F4/80; DD7A5-; DD7A5-7; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-TM7; Emr; Emr1; EMR1 hormone receptor; F4/80; Gpf480; Ly7; Ly71; lymphocyte antigen 71; TM7L; TM7LN3
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Gene Symbols: Adgre1
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Molecular weight:
102,130 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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