ADAM8 Possible involvement in extravasation of leukocytes. Expressed on neutrophils and monocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component:  alpha9-beta1 integrin-ADAM8 complex; cell surface; cytoplasm; dense core granule membrane; ficolin-1-rich granule membrane; integral component of plasma membrane; phagolysosome; plasma membrane; podosome; specific granule; specific granule membrane; tertiary granule; tertiary granule membrane
Molecular Function:  calcium ion binding; cell adhesion molecule binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding
Biological Process:  angiogenesis; cell morphogenesis; cell-cell adhesion; cellular response to hypoxia; extracellular matrix disassembly; inflammatory response; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptotic process; neutrophil degranulation; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of eosinophil migration; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of innate immune response; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of neutrophil extravasation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; positive regulation of protein processing; positive regulation of protein secretion; positive regulation of T cell differentiation in thymus; positive regulation of thymocyte apoptotic process; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; proteolysis; regulation of cell-cell adhesion
Reference #:  P78325 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 8; ADAM 8; ADAM metallopeptidase domain 8; ADAM8; CD156; CD156a; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; MGC134985; MS2
Gene Symbols: ADAM8
Molecular weight: 88,771 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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