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MXD3
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 5q35.3 |
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Cellular Component:
chromatin; RNA polymerase II transcription regulator complex
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Reference #:
Q9BW11
(UniProtKB)
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Alt. Names/Synonyms: BHLHC13; Class C basic helix-loop-helix protein 13; FLJ35523; MAD3; Max dimerization protein 3; Max dimerizer 3; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; MGC2383; MXD3; Myx
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Gene Symbols: MXD3
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Molecular weight:
23,477 Da
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Basal Isoelectric point:
9.32
Predict pI for various phosphorylation states
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