|
ADAM8
Possible involvement in extravasation of leukocytes. Expressed on neutrophils and monocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease |
| Chromosomal Location of mouse Ortholog: 7|7 F4 |
|
Cellular Component:
alpha9-beta1 integrin-ADAM8 complex; cell surface; cytoplasm; dense core granule membrane; membrane; phagolysosome; plasma membrane; podosome; specific granule; tertiary granule
|
|
Molecular Function:
calcium ion binding; cell adhesion molecule binding; hydrolase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding
|
|
Biological Process:
angiogenesis; blood vessel endothelial cell migration; cell morphogenesis; cell-cell adhesion; cell-matrix adhesion; cellular response to hypoxia; inflammatory response; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; membrane fusion; negative regulation of neuron apoptotic process; negative regulation of thymocyte aggregation; osteoclast fusion; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of cellular extravasation; positive regulation of eosinophil migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of inflammatory response; positive regulation of innate immune response; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of neutrophil extravasation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; positive regulation of T cell differentiation in thymus; positive regulation of T cell migration; positive regulation of thymocyte apoptotic process; positive regulation of transforming growth factor beta1 activation; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; proteolysis; regulation of cell-cell adhesion; regulation of osteoclast differentiation; tissue morphogenesis
|
|
Reference #:
Q05910
(UniProtKB)
|
|
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 8; a disintegrin and metalloprotease domain (ADAM) 8; a disintegrin and metalloprotease domain 8; ADAM 8; Adam8; CD156; CD156a; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; E430039A18Rik; Macrophage cysteine-rich glycoprotein; Ms2; OTTMUSP00000023515
|
|
Gene Symbols: Adam8
|
|
Molecular weight:
90,046 Da
|
|
Basal Isoelectric point:
8.22
Predict pI for various phosphorylation states
|
