SFRS3 Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific. Belongs to the splicing factor SR family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17 A3.3|17 15.03 cM
Cellular Component:  cytoplasm; nuclear speck; nucleus
Molecular Function:  nucleic acid binding; phospholipase binding; RNA binding; sequence-specific mRNA binding
Biological Process:  cellular response to leukemia inhibitory factor; insulin receptor signaling pathway; mRNA cis splicing, via spliceosome; mRNA export from nucleus; mRNA processing; mRNA transport; regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome; RNA splicing
Reference #:  P84104 (UniProtKB)
Alt. Names/Synonyms: AL024116; Pre-mRNA-splicing factor SRP20; Protein X16; serine and arginine-rich splicing factor 3; Serine/arginine-rich splicing factor 3; Sfrs3; Splicing factor, arginine/serine-rich 3; splicing factor, arginine/serine-rich 3 (SRp20); Srp20; Srsf3; X16
Gene Symbols: Srsf3
Molecular weight: 19,330 Da
Basal Isoelectric point: 11.64  Predict pI for various phosphorylation states
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SFRS3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene