RAB1A The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. Belongs to the small GTPase superfamily. Rab family. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 2p14
Cellular Component:  cytosol; early endosome; Golgi membrane; melanosome; transport vesicle membrane
Molecular Function:  GTP binding; GTPase activity; protein binding
Biological Process:  autophagosome assembly; autophagy; cargo loading into COPII-coated vesicle; cell migration; COPII vesicle coating; defense response to bacterium; endocytosis; ER to Golgi vesicle-mediated transport; Golgi organization; growth hormone secretion; interleukin-8 secretion; melanosome transport; positive regulation of glycoprotein metabolic process; positive regulation of ubiquitin protein ligase activity; post-translational protein modification; retrograde vesicle-mediated transport, Golgi to ER; substrate adhesion-dependent cell spreading; vesicle transport along microtubule; vesicle-mediated transport; virion assembly
Reference #:  P62820 (UniProtKB)
Alt. Names/Synonyms: DKFZp564B163; GTP binding protein Rab1a; Rab GTPase YPT1 homolog; RAB1; RAB1, member RAS oncogene family; RAB1A; RAB1A, member RAS oncogene family; Ras-related protein Rab-1A; YPT1; YPT1-related protein
Gene Symbols: RAB1A
Molecular weight: 22,678 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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