RAB1A The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. Belongs to the small GTPase superfamily. Rab family. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 11 A3.1|11 12.92 cM
Cellular Component:  cytoplasm; early endosome; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; Golgi apparatus; Golgi membrane; melanosome; membrane; neuronal cell body; presynapse
Molecular Function:  GTP binding; GTPase activity; nucleotide binding; protein binding
Biological Process:  autophagosome assembly; autophagy; cargo loading into COPII-coated vesicle; cell migration; defense response to bacterium; endocytosis; ER to Golgi vesicle-mediated transport; Golgi organization; growth hormone secretion; interleukin-8 secretion; intracellular protein transport; melanosome transport; positive regulation of glycoprotein metabolic process; protein transport; Rab protein signal transduction; substrate adhesion-dependent cell spreading; vesicle transport along microtubule; vesicle-mediated transport; virion assembly
Reference #:  P62821 (UniProtKB)
Alt. Names/Synonyms: Gtb; Gtbp; mKIAA3012; Rab; Rab-1; Rab1; RAB1, member RAS oncogene family; Rab1A; RAB1A, member RAS oncogene family; Ras-related protein Rab-1A; ras-related YPT1 protein; Ypt; Ypt1; YPT1-related protein
Gene Symbols: Rab1A
Molecular weight: 22,678 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene