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RRas2
It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. Belongs to the small GTPase superfamily. Ras family. Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of human Ortholog: 11p15.2 |
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Cellular Component:
endoplasmic reticulum; Golgi membrane; plasma membrane
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Molecular Function:
GDP binding; GTP binding; GTPase activity; protein binding
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Biological Process:
positive regulation of Schwann cell migration; Ras protein signal transduction; Schwann cell migration
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Disease: Noonan Syndrome 12
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Reference #:
P62070
(UniProtKB)
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Alt. Names/Synonyms: NS12; RAS related 2; Ras-like protein TC21; Ras-related protein R-Ras2; related RAS viral (r-ras) oncogene homolog 2; RRAS2; TC21; Teratocarcinoma oncogene
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Gene Symbols: RRAS2
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Molecular weight:
23,400 Da
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Basal Isoelectric point:
5.74
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Angiogenesis
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B Cell Receptor Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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IL6 Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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T Cell Receptor Signaling
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Warburg Effect
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