RAB8B The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component:  cell tip; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; perinuclear region of cytoplasm; peroxisomal membrane; phagocytic vesicle; phagocytic vesicle membrane; recycling endosome membrane
Molecular Function:  GDP binding; GTP binding; GTPase activity; protein binding; signaling receptor binding; TPR domain binding
Biological Process:  adherens junction organization; antigen processing and presentation; positive regulation of cell projection organization; positive regulation of corticotropin secretion; protein import into peroxisome membrane
Reference #:  Q92930 (UniProtKB)
Alt. Names/Synonyms: FLJ38125; RAB-8b protein; RAB8B; RAB8B, member RAS oncogene family; Ras-related protein Rab-8B
Gene Symbols: RAB8B
Molecular weight: 23,584 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB