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RAB10
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab |
| Chromosomal Location of human Ortholog: 2p23.3 |
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Cellular Component:
cilium; cytoplasmic vesicle membrane; cytoskeleton; cytosol; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endosome; exocytic vesicle; Golgi apparatus; Golgi membrane; insulin-responsive compartment; perinuclear region of cytoplasm; phagocytic vesicle membrane; plasma membrane; recycling endosome; recycling endosome membrane; secretory granule membrane; trans-Golgi network
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Molecular Function:
G protein activity; GDP binding; GTP binding; myosin V binding; protein binding
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Biological Process:
antigen processing and presentation; axonogenesis; cell-cell adhesion; cellular response to insulin stimulus; endoplasmic reticulum tubular network organization; endosomal transport; establishment of neuroblast polarity; establishment of protein localization to endoplasmic reticulum membrane; establishment of protein localization to membrane; Golgi to plasma membrane protein transport; Golgi to plasma membrane transport; polarized epithelial cell differentiation; protein localization to basolateral plasma membrane; protein localization to plasma membrane; regulated exocytosis; vesicle-mediated transport
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Reference #:
P61026
(UniProtKB)
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Alt. Names/Synonyms: GTP-binding protein RAB10; RAB10; RAB10, member RAS oncogene family; ras-related GTP-binding protein; Ras-related protein Rab-10
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Gene Symbols: RAB10
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Molecular weight:
22,541 Da
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Basal Isoelectric point:
8.58
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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