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RAB8A
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis. Involved in autophagy. Belongs to the small GTPase superfamily. Rab family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of Human Ortholog: 19p13.11 |
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Cellular Component:
centriole; centrosome; ciliary basal body; ciliary base; cilium; cytosol; glutamatergic synapse; Golgi membrane; midbody; neuronal cell body; non-motile cilium; phagocytic vesicle; phagocytic vesicle membrane; postsynaptic density; recycling endosome membrane; trans-Golgi network membrane
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Molecular Function:
GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding; protein kinase binding; Rab GTPase binding
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Biological Process:
autophagy; axonogenesis; cellular response to insulin stimulus; cilium assembly; Golgi vesicle fusion to target membrane; neurotransmitter receptor transport, endosome to postsynaptic membrane; post-translational protein modification; protein localization to plasma membrane; regulation of autophagy; regulation of long-term neuronal synaptic plasticity; regulation of protein transport; vesicle docking involved in exocytosis; vesicle-mediated transport in synapse
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Reference #:
P61006
(UniProtKB)
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Alt. Names/Synonyms: MEL; mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); Oncogene c-mel; RAB8; RAB8A; RAB8A, member RAS oncogene family; ras-associated protein RAB8; Ras-related protein Rab-8A
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Gene Symbols: RAB8A
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Molecular weight:
23,668 Da
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Basal Isoelectric point:
9.15
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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