ATP6V1E1 Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase E subunit family. Ubiquitous (PubMed:12036578). High expression in the skin (PubMed:28065471). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial
Chromosomal Location of Human Ortholog: 6 F1|6 57.01 cM
Cellular Component:  apical plasma membrane; cytoplasm; cytosol; endosome; microvillus; proton-transporting two-sector ATPase complex, catalytic domain
Molecular Function:  ATPase binding; hydrolase activity; protein binding; proton-exporting ATPase activity, phosphorylative mechanism; proton-transporting ATPase activity, rotational mechanism
Biological Process:  ATP hydrolysis coupled proton transport; ion transport
Reference #:  P50518 (UniProtKB)
Alt. Names/Synonyms: 2410029D23Rik; Atp; Atp6; Atp6e; Atp6e2; Atp6v1e; Atp6v1e1; ATPase, H+ transporting lysosomal (vacuolar proton pump), 32 kDa; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E; ATPase, H+ transporting, lysosomal V1 subunit E1; ATPase, H+ transporting, V1 subunit E; D6Ertd385; D6Ertd385e; E2; H(+)-ATPase E-like protein; H+ ATPase subunit E; lysosomal 31kDa; p31; V-ATPase 31 kDa subunit; V-ATPase subunit E 1; V-type proton ATPase subunit E 1; Vacuolar proton pump subunit E 1; VATE1; VATPase, H+ transporting, lysosomal V1 subunit E1; Vma4
Gene Symbols: Atp6v1e1
Molecular weight: 26,157 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
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ATP6V1E1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene