Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase E subunit family. Ubiquitous (PubMed:12036578). High expression in the skin (PubMed:28065471). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial