GOT2 Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC; EC; Mitochondrial; Transferase
Chromosomal Location of human Ortholog: 16q21
Cellular Component:  cell surface; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; perikaryon; plasma membrane; protein-containing complex; T-tubule
Molecular Function:  amino acid binding; enzyme binding; kynurenine-oxoglutarate transaminase activity; L-aspartate:2-oxoglutarate aminotransferase activity; phospholipid binding; protein homodimerization activity; pyridoxal phosphate binding
Biological Process:  2-oxoglutarate metabolic process; 4-hydroxyproline catabolic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; cellular amino acid biosynthetic process; fatty acid transport; female pregnancy; gluconeogenesis; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; glyoxylate metabolic process; L-kynurenine metabolic process; lactation; oxaloacetate metabolic process; response to ethanol; response to insulin; response to morphine; response to muscle activity
Disease: Epileptic Encephalopathy, Early Infantile, 82
Reference #:  P00505 (UniProtKB)
Alt. Names/Synonyms: AATM; aspartate aminotransferase 2; Aspartate aminotransferase, mitochondrial; aspartate transaminase 2; FABP-1; FABPpm; Fatty acid-binding protein; FLJ40994; Glutamate oxaloacetate transaminase 2; glutamic-oxaloacetic transaminase 2; glutamic-oxaloacetic transaminase 2, mitochondrial; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); GOT2; KAT4; KATIV; KYAT4; Kynurenine aminotransferase 4; kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; mAspAT; mitAAT; Plasma membrane-associated fatty acid-binding protein; Transaminase A
Gene Symbols: GOT2
Molecular weight: 47,518 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene