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GOT2
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.7; Mitochondrial; Transferase |
| Chromosomal Location of mouse Ortholog: 8 D1|8 47.79 cM |
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Cellular Component:
cell surface; membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; perikaryon; plasma membrane; protein-containing complex; sarcolemma; T-tubule
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Molecular Function:
amino acid binding; carboxylic acid binding; catalytic activity; enzyme binding; identical protein binding; kynurenine-oxoglutarate transaminase activity; L-aspartate:2-oxoglutarate aminotransferase activity; phospholipid binding; pyridoxal phosphate binding; transaminase activity; transferase activity
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Biological Process:
amino acid metabolic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; biosynthetic process; dicarboxylic acid metabolic process; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; lipid transport; oxaloacetate metabolic process; response to ethanol
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Reference #:
P05202
(UniProtKB)
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Alt. Names/Synonyms: AATM; AL022787; Aspartate aminotransferase, mitochondrial; FABP; FABP-1; FABP-pm; FABPpm; Fatty acid-binding protein; Glutamate oxaloacetate transaminase 2; glutamate oxaloacetate transaminase 2, mitochondrial; glutamatic-oxaloacetic transaminase 2, mitochondrial; Got-2; Got2; Kyat; Kyat4; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; mAspAT; MGC102129; MGC115763; mitochondrial aspartate aminotransferase; OTTMUSP00000017748; plasma membrane fatty acid binding protein; Plasma membrane-associated fatty acid-binding protein; Transaminase A
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Gene Symbols: Got2
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Molecular weight:
47,411 Da
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Basal Isoelectric point:
9.13
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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