DHCR7 Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). Belongs to the ERG4/ERG24 family. Most abundant in adrenal gland, liver, testis, and brain. Note: This description may include information from UniProtKB.
Protein type: EC 1.3.1.21; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; nuclear outer membrane
Molecular Function:  7-dehydrocholesterol reductase activity; NADP binding
Biological Process:  blood vessel development; cell differentiation; cholesterol biosynthetic process; cholesterol biosynthetic process via desmosterol; cholesterol biosynthetic process via lathosterol; lung development; multicellular organism growth; oxidation-reduction process; post-embryonic development; regulation of cell proliferation; regulation of cholesterol biosynthetic process
Disease: Smith-lemli-opitz Syndrome
Reference #:  Q9UBM7 (UniProtKB)
Alt. Names/Synonyms: 7-dehydrocholesterol reductase; 7-DHC reductase; D7SR; delta-7-dehydrocholesterol reductase; Delta7-sterol reductase; DHCR7; Putative sterol reductase SR-2; SLOS; Sterol Delta(7)-reductase; sterol delta-7-reductase; Sterol reductase SR-2
Gene Symbols: DHCR7
Molecular weight: 54,489 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
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DHCR7

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein