AVIL Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component:  actin cytoskeleton; axon; cell projection; cytoplasm; neuron projection
Molecular Function:  actin binding; actin filament binding
Biological Process:  actin filament capping; cilium assembly; cytoskeleton organization; nervous system development; positive regulation of neuron projection development
Disease: Nephrotic Syndrome, Type 21
Reference #:  O75366 (UniProtKB)
Alt. Names/Synonyms: ADVIL; Advillin; AVIL; DKFZp779O1812; DOC6; FLJ12386; MGC133244; NPHS21; p92
Gene Symbols: AVIL
Molecular weight: 92,027 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
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AVIL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene