|
AVIL
Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 12q14.1 |
|
Cellular Component:
actin cytoskeleton; actin filament; axon; cell projection; cytoplasm; focal adhesion; lamellipodium; neuron projection
|
|
Molecular Function:
actin binding; actin filament binding; Arp2/3 complex binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding
|
|
Biological Process:
actin filament organization; actin filament severing; actin polymerization or depolymerization; barbed-end actin filament capping; cilium assembly; nervous system development; positive regulation of lamellipodium assembly; positive regulation of neuron projection development; regulation of diacylglycerol biosynthetic process
|
|
Disease: Nephrotic Syndrome, Type 21
|
|
Reference #:
O75366
(UniProtKB)
|
|
Alt. Names/Synonyms: ADVIL; Advillin; AVIL; DKFZp779O1812; DOC6; FLJ12386; MGC133244; NPHS21; p92
|
|
Gene Symbols: AVIL
|
|
Molecular weight:
92,027 Da
|
|
Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
|
