AVIL Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 10|10 D3
Cellular Component:  cell projection; cytoplasm; cytoskeleton; neuron projection
Molecular Function:  actin binding; actin filament binding; protein binding
Biological Process:  actin filament capping; actin filament organization; cilium assembly; cytoskeleton organization; nervous system development; positive regulation of neuron projection development
Reference #:  O88398 (UniProtKB)
Alt. Names/Synonyms: Actin-binding protein DOC6; Advil; Advillin; Avil; DOC; DOC6; p92
Gene Symbols: Avil
Molecular weight: 92,032 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
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AVIL

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene