MBD1 Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 18 E2|18 50.7 cM
Cellular Component:  chromatin; chromosome; cytoplasm; heterochromatin; nuclear chromatin; nuclear matrix; nuclear speck; nucleus
Molecular Function:  chromatin binding; DNA binding; double-stranded methylated DNA binding; metal ion binding; methyl-CpG binding; protein binding; zinc ion binding
Biological Process:  methylation-dependent chromatin silencing; negative regulation of astrocyte differentiation; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II
Reference #:  Q9Z2E2 (UniProtKB)
Alt. Names/Synonyms: Cxxc3; Mbd1; methyl-CpG binding domain protein 1; Methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1
Gene Symbols: Mbd1
Molecular weight: 70,023 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene