PPP6C Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation. Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily. Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 2|2 B
Cellular Component:  cytoplasm; cytosol; mitochondrion
Molecular Function:  hydrolase activity; metal ion binding; phosphoprotein phosphatase activity; protein serine/threonine phosphatase activity
Biological Process:  cell cycle; immune system process; innate immune response; protein dephosphorylation
Reference #:  Q9CQR6 (UniProtKB)
Alt. Names/Synonyms: 2310003C10Rik; OTTMUSP00000013324; PP6C; PPP6; Ppp6c; protein phosphatase 6, catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit
Gene Symbols: Ppp6c
Molecular weight: 35,159 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Select Structure to View Below

PPP6C

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene