p27Kip1 a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 12p13.1
Cellular Component:  Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; cytosol; endosome; intracellular membrane-bounded organelle; nucleoplasm; nucleus
Molecular Function:  cyclin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; Hsp70 protein binding; protein binding; protein kinase binding; protein kinase inhibitor activity; protein phosphatase binding; protein-containing complex binding; transforming growth factor beta receptor, cytoplasmic mediator activity
Biological Process:  autophagic cell death; cell cycle arrest; cellular response to antibiotic; cellular response to lithium ion; cellular response to organic cyclic compound; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; heart development; inner ear development; mitotic cell cycle arrest; negative regulation of apoptotic process; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cellular component movement; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-templated; negative regulation of vascular smooth muscle cell proliferation; Notch signaling pathway; placenta development; positive regulation of cell cycle; positive regulation of cell death; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; potassium ion transport; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of exit from mitosis; regulation of lens fiber cell differentiation; response to amino acid; response to cadmium ion; response to drug; response to estradiol; response to glucose; response to hypoxia; response to peptide hormone; sensory perception of sound
Disease: Multiple Endocrine Neoplasia, Type Iv
Reference #:  P46527 (UniProtKB)
Alt. Names/Synonyms: CDKN1B; CDKN4; CDN1B; Cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; KIP1; MEN1B; MEN4; p27Kip1
Gene Symbols: CDKN1B
Molecular weight: 22,073 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G1/S Checkpoint  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB